Subject(s)
Humans , Male , Adult , Histiocytoma, Benign Fibrous/diagnosis , Mediastinal Neoplasms/pathology , Antibiotics, Antineoplastic/therapeutic use , Cyclophosphamide/therapeutic use , Dacarbazine/therapeutic use , Dimethoate/therapeutic use , Histiocytoma, Benign Fibrous/drug therapy , Histiocytoma, Benign Fibrous/surgery , Mediastinal Neoplasms/diagnosis , Neoplasm Recurrence, Local , Survival Rate , Vincristine/therapeutic useABSTRACT
Apresentamos um caso de fibro-histiocitoma maligno retroperitoneal complicado por hemorragia espontânea intracavitária, sendo esta uma forma de apresentaçäo muito atípica. Os fibro-hitiocitomas malignos säo tipos comuns de sarcoma, porém, a sua localizaçäo no retroperitônio, com invasäo da cavidade peritoneal a partir deste sítio primário, é muito rara. Como todos os tumores do retroperitônio, o diagnóstico precoce é difícil, poi suas apresentaçöes clínica, laboratorial e radiológica säo inespecíficas e näo permitem o diagnóstico definitivo. A paciente foi submetida a uma laparotomia de urgência, que foi diagnóstica e terapêutica. Os autores reportam este caso enfatizando o diagnóstico, tratamento e evoluçäo
Subject(s)
Humans , Female , Middle Aged , Abdomen, Acute/etiology , Hemoperitoneum/etiology , Histiocytoma, Benign Fibrous/diagnosis , Retroperitoneal Neoplasms/diagnosis , Antibiotics, Antineoplastic , Antineoplastic Agents, Phytogenic , Doxorubicin/therapeutic use , Histiocytoma, Benign Fibrous/complications , Histiocytoma, Benign Fibrous/drug therapy , Histiocytoma, Benign Fibrous/surgery , Retroperitoneal Neoplasms/complications , Retroperitoneal Neoplasms/drug therapy , Retroperitoneal Neoplasms/surgery , Vincristine/therapeutic useABSTRACT
Os objetivos do presente trabalho foram estdar os efeitos da deficiência aguda de tiamina no crescimento e na resposta quimiterápica de um fibro-histiocitoma maligno no rato. Para tanto, ratos foram inoculados por via subcutânea com suspensäo de células tumorais e divididos em quadro grupos, de 10 animais cada: DCT - alimentados com dieta sem tiamina; TGT - alimentados com dieta controle; e TVC - alimentados com dieta controle e tratados com SVC. Os animais tratados com SVC (DVC e TVC) apresentaram diminuiçäo de volume tumoral quando comparados com os näo tratados (DCT e TCT). Entretanto, näo houve alteraçäo no volume tumoral de animais carentes em tiamina tratados (DVC) em relaçäo àqueles tratados e com dieta controle (DCT). Estes dados indicam que a deficiência aguda de tiamina per se näo altera o cresciento do FHM como também näo modifica a resposta de tumor frente à quimioterapia com SVC.
Subject(s)
Animals , Male , Rats , Histiocytoma, Benign Fibrous/metabolism , Thiamine Deficiency/metabolism , Body Weight , Histiocytoma, Benign Fibrous/drug therapy , Injections, Intraperitoneal , Rats, Wistar , VincristineABSTRACT
Between June 1985 and March 1990, 25 patients with primary malignant bone tumors, including 15 cases of osteogenic sarcoma, two cases of periosteal osteogenic sarcoma, six cases of chondrosarcoma, and two cases of malignant fibrous histiocytoma, were treated with limb-salvage procedures. Fourteen patients underwent limb salvage operations with tumor prosthesis arthroplasty, 6 with resection-arthrodesis, 4 with wide resection, and 1 with autoclaved autograft. Pre- and/or post-operative chemotherapy with or without radiotherapy was combined with these limb salvage operations. The average follow-up period was 25.2 months (6 to 52 months) since diagnosis. The estimated 3.5-year survival rate of the total 25 patients was 39.5% based on the Kaplan-Meier survival plot. In the 15 cases of osteogenic sarcoma, the estimated Kaplan-Meier 34-month survival rate was 46.2%. Seventeen patients who were followed up for more than 1 year were grouped by functional grading: 11 (65%) were excellent; 3 (18%) good; 2 fair (12%); and 1 poor. Complications occurred in 4 patients, 1 had a local recurrence, 2 had superficial wound infections, and 1 a loosening of the femoral stem. Metastases were shown in 15 case, and the most common location was the lung.
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Arthroplasty , Bone Neoplasms/drug therapy , Chondrosarcoma/drug therapy , Combined Modality Therapy , Follow-Up Studies , Histiocytoma, Benign Fibrous/drug therapy , Lung Neoplasms/secondary , Neoplasm Recurrence, Local , Osteosarcoma/drug therapy , Survival AnalysisABSTRACT
Los angiomas palpebrales con oclusión ocular parcial o total pueden producir secuelas irreversibles como la ampliopía, de ahí la importancia de su tratamiento precoz y agresivo. Los autores discuten los efectos terapéuticos de una asociación de Betametasona y Triamcinolona intralesional en los angiomas de 10 pacientes de sexo femenino, y los resultados obtenidos. la acción de la corticoterapia sobre el crecimiento de las niñas tratadas fue controlada a través de la determinación de la edad ósea y del ritmo de crecimiento